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Three thousand five hundred years of sheeppox virus evolution inferred from archaeological and codicological genomes Научная публикация

Журнал Science Advances
ISSN: 2375-2548
Вых. Данные Год: 2026, Том: 12, Номер: 36, DOI: 10.1126/sciadv.aeh3571
Авторы L’Hôte Louis 3 , Sacristán Luisa 3 , Ferguson Róisín 3 , Siekmann Alex 3 , Rogers Leland 3 , Richter Barbara 3 , Weissenböck Herbert 3 , Lorke Jenny 3 , Artemis Lara 3 , Lévêque Élodie 3 , Hark Richard 3 , Engel Patricia 3 , Webber Mary Teresa Josephine 3 , Bennett Madison 3 , Rose-Beers Kristine 3 , Nichols Emma 3 , Munoz Alegre Marta 3 , Ramsøe Max 3 , Fiddyment Sarah 3 , Viñas-Caron Laura C. 3 , Papin Dimitry V. 1,2 , Light-Maka Ian C. 3 , Key Felix M. 3 , Albarnaz Jonas 3 , Downing Tim 3 , Pekar Jonathan 3 , Lemey Philippe 3 , Bradley Daniel G. 3 , Vnouček Jiří 3 , Makarewicz Cheryl A. 3 , Story Joanna 3 , Collins Matthew 3 , Teasdale Matthew D. 3 , Binois-Roman Annelise 3 , Calvignac-Spencer Sébastien 3 , Daly Kevin G. 3
Организации
1 Institute of Archaeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2 Altai State University, Barnaul, Russia.
3 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland. School of Biological Sciences, University of East Anglia, Norwich, UK. Institute for Prehistoric and Protohistoric Archaeology, University of Kiel, Kiel, GermanyUniversity of North Carolina, Wilmington, NC 28403, USA. Institute of Pathology, Center of Pathobiology, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria

Реферат: Sheeppox virus (SPPV) is a major livestock pathogen causing economic hardship through reduced production and death of vulnerable sheep, with written descriptions of sheeppox-like disease recorded since antiquity. We report 21 novel ancient SPPV genomes spanning the Eurasian steppe Bronze Age (∼1700 BCE) to the Early Modern period in Western Europe, including multiple genomes obtained from medieval parchment. We estimate that major capripoxvirus lineages diverged ∼11,500 to 3700 years ago, overlapping known translocations and bio-cultural developments in sheep. Our dataset supports SPPV diverging first within the lineage leading to goatpox virus and lumpy skin disease virus, and that known gene inactivation events within SPPV and goatpox virus occur in our earliest SPPV genomes. These findings reveal that the food security of Eurasian communities has been threatened by sheeppox for more than 3700 years and provide insights into the genomic evolution and potential host adaptation of SPPV.
Библиографическая ссылка: L’Hôte L. , Sacristán L. , Ferguson R. , Siekmann A. , Rogers L. , Richter B. , Weissenböck H. , Lorke J. , Artemis L. , Lévêque É. , Hark R. , Engel P. , Webber M.T.J. , Bennett M. , Rose-Beers K. , Nichols E. , Munoz Alegre M. , Ramsøe M. , Fiddyment S. , Viñas-Caron L.C. , Papin D.V. , Light-Maka I.C. , Key F.M. , Albarnaz J. , Downing T. , Pekar J. , Lemey P. , Bradley D.G. , Vnouček J. , Makarewicz C.A. , Story J. , Collins M. , Teasdale M.D. , Binois-Roman A. , Calvignac-Spencer S. , Daly K.G.
Three thousand five hundred years of sheeppox virus evolution inferred from archaeological and codicological genomes
Science Advances. 2026. V.12. N36. DOI: 10.1126/sciadv.aeh3571 WOS
Даты:
Опубликована online: 2 сент. 2026 г.
Идентификаторы БД:
≡ Web of science: WOS:001865805300009
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